By José Marín-García M.D., Michael J. Goldenthal, Gordon W. Moe (auth.)

Cardiac getting older, like getting older commonly, is a posh strategy. quite a few mobile and molecular alterations give a contribution to the expression of the a number of phenotypes of getting older, "the various faces" of cardiac getting older. during this ebook, the genetic and molecular foundation of cardiovascular getting older might be mentioned. additionally, a finished evaluation of the bioenergetic adjustments that ensue in human and animal types of cardiac getting older in addition to present diagnostic and destiny healing modalities could be undertaken.

José Marín-García is Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey.

Show description

Read Online or Download Aging and the Heart: A Post-Genomic View PDF

Similar nonfiction_9 books

The Rise of the Network Society: With a New Preface, Volume I, Second edition With a new preface

This primary booklet in Castells' groundbreaking trilogy, with a considerable new preface, highlights the commercial and social dynamics of the knowledge age and exhibits how the community society has now totally risen on a world scale. Groundbreaking quantity at the impression of the age of data on all elements of society comprises assurance of the impact of the net and the net-economy Describes the accelerating velocity of innovation and social transformation in response to examine within the united states, Asia, Latin the United States, and Europe content material: bankruptcy 1 the knowledge know-how Revolution (pages 28–76): bankruptcy 2 the recent economic climate: Informationalism, Globalization, Networking (pages 77–162): bankruptcy three The community company: The tradition, associations, and businesses of the Informational financial system (pages 163–215): bankruptcy four The Transformation of labor and Employment: Networkers, Jobless, and Flex?

The Neuronal Microenvironment

Innovations within the neurosciences are evolving speedily. There are at present only a few volumes devoted to the method - ployed by means of neuroscientists, and those who can be found frequently appear both outdated or constrained in scope. This sequence is set the equipment most generally utilized by modern day neuroscientists and is written via their colleagues who're practising specialists.

Genitourinary Radiology: Kidney, Bladder and Urethra: The Pathologic Basis

Genitourinary Radiology: Kidney, Bladder and Urethra: The Pathologic foundation is the 1st quantity in a collection of books at the pathologic foundation of genitourinary radiology. Genitourinary Radiology: Kidney, Bladder and Urethra: The Pathologic foundation offers a lavishly illustrated consultant to the radiologic and pathologic positive factors of a large spectrum of genitourinary illnesses of the urinary tract, together with the entities most typically encountered in everyday perform.

Human Retroviruses: Methods and Protocols

Human Retroviruses: tools and Protocols collects key experimental protocols that experience supplied the root of the main discoveries of the sphere. cut up into 5 sections, this targeted quantity covers mapping of the HIV lifestyles cycle, isolation, co-receptor use, and mobile tropism of HIV-1, in vivo quantification of HIV-1, organic facets of HIV-1, in addition to HTLVs.

Additional info for Aging and the Heart: A Post-Genomic View

Sample text

Temperature drop in winter) than by lethal ones. ). In particular one of them, hypergravity decreases the rate of behavioral aging. At this time the mechanisms whereby these stresses increase longevity are not clear, although they may involve metabolic regulation and induction of stress protein such as heat shock proteins (HSPs). It is worth noting than in response to increased level of ROS in the senescent heart, genes encoding mitochondrial stress proteins including both heat shock and antioxidant response proteins, such as HSP60, HO-1 and GPx are up-regulated [139].

Elephants), such as increasing knowledge, leadership, well being, relationships and creativity. References 1. Luciani F, Valensin S, Vescovini R, Sansoni P, Fagnoni F, Franceschi C, Bonafe M, Turchetti G. A stochastic model for CD8(+)T cell dynamics in human immunosenescence: implications for survival and longevity. J Theor Biol 2001;213:587–597 2. De Benedictis G, Tan Q, Jeune B, Christensen K, Ukraintseva SV, Bonafe M, Franceschi C, Vaupel JW, Yashin AI. Recent advances in human gene-longevity association studies.

H2 O2 production and oxidative damage) and increased genomic stability as indicated by reduced levels of mtDNA deletions in both heart and skeletal muscle. The observation that a relatively large increase in life span results from the up-regulation of a single gene involved in boosting antioxidant defenses, and its targeting to the mitochondria, buttresses the notion that mitochondrial ROS and OS play a critical role in determining life span, and are to date the most compelling support for FRTA.

Download PDF sample

Rated 4.68 of 5 – based on 22 votes